The iconic actress joins her former co-stars to raise funds for the Race to End MS initiative.

October 29, 2025: Christina Applegate is set to reunite with her Married With Children family for a special cause close to her heart. The Emmy-winning actress, who has been open about her battle with multiple sclerosis (MS), will join her former co-stars in a cast reunion event aimed at raising money for the Race to End MS foundation.

A Reunion with Purpose

The event marks a rare on-screen reunion for the beloved cast of the hit sitcom, which aired from 1987 to 1997. Applegate, alongside Ed O’Neill, Katey Sagal, and David Faustino, will come together for an evening filled with laughter, nostalgia, and heartfelt moments — all in support of MS research and awareness.

Christina’s Ongoing Fight Against MS

Since publicly revealing her MS diagnosis in 2021, Applegate has become an outspoken advocate for those living with the condition. Despite her health challenges, the Dead to Me star continues to use her platform to bring attention to the realities of MS and the need for continued funding for medical research.

Fans Excited for a Heartfelt Reunion

Fans are eagerly awaiting this reunion, both to see the cast together again and to support the cause. The Married With Children cast’s involvement in the Race to End MS highlights the power of using entertainment for positive change.