Eric Dane Battles ALS with Grace and Love — Filmmaker Janell Shirtcliff Stands Strong by His Side

June 19, 2025: Eric Dane, best known for Grey’s Anatomy and Euphoria, has been publicly battling amyotrophic lateral sclerosis (ALS)—a neurodegenerative disease—since announcing his diagnosis in April 2025.
Despite mounting health challenges, including complete loss of function in his right arm and deterioration in his left , Dane has found strength and comfort in his romantic relationship with filmmaker Janell Shirtcliff, his partner of over three years. According to People, the couple was spotted affectionately attending the Countdown premiere in Los Angeles together, marking his first public outing since going public about his ALS.

Shirtcliff Provides Vital Support

Shirtcliff’s presence at the red carpet event underscores a deeply supportive dynamic. Over the course of Dane’s on-and-off relationship with Shirtcliff, she has reportedly remained a constant pillar, offering emotional and practical assistance during this difficult period. Meanwhile, Dane continues to express gratitude toward his estranged wife, Rebecca Gayheart, praising her unwavering support and co-parenting as they manage life’s challenges together.

Family, Love, and Career on His Mind

Diagnosed in April, Dane wasted little time returning to work—rejoining the set of Euphoria just four days later with filming beginning April 14. In recent interviews, he’s been candid about the physical toll of ALS, including losing the use of his right arm and a near-drowning incident that required his daughter’s intervention. Despite these obstacles, Eric remains determined to continue acting: “I’m going to ride this ‘til the wheels fall off,” he told E! News.

Love Story Amid Adversity

Eric Dane and Janell Shirtcliff first connected in 2022 and have sustained their relationship through ups and downs. The filmmaker has become not just a romantic partner, but a “supportive presence” navigating a major health crisis alongside him. Their relationship contrasts in many ways with Dane’s co-parenting arrangement with Gayheart—and illustrates how love and companionship can take many forms, even amid hardship.

What’s Next for Dane

As ALS typically progresses over 3–5 years, Eric faces an uncertain path. But with Shirtcliff’s support, his family’s care, and renewed focus on his career, he remains optimistic. Dane has requested privacy while continuing to champion ALS awareness and maintain his creative engagements.